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KMID : 1143120150050030187
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Asia Pacific Allergy
2015 Volume.5 No. 3 p.187 ~ p.190
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Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis
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Jung Hwa-Sik
Park Chan-Ho
Park Young-Tae
Bae Mi-Ae
Lee Youn-Im
Kang Byung-Ju
Jegal Yang-Jin
Ahn Jong-Joon
Lee Tae-Hoon
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Abstract
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H1-antihistamine is generally a well-tolerated and safe drug. However, in resemblance with all other drugs, H1-antihistamines can also prompt adverse drug reactions (ADRs). We recently encountered the very unusual ADR of H1-antihistamine-induced gynecomastia. A 21-year-old man with idiopathic anaphylaxis was treated with ebastine (Ebastel), a second-generation H1-antihistamine, for the prevention of anaphylaxis. Three months later, the patient remained well without anaphylaxis, but had newly developed gynecomastia. Because anaphylaxis recurred after the cessation of H1-antihistamine, the preventive medication was changed to omalizumab. A few months later, his gynecomastia had entirely disappeared. Physicians should be aware of this exceptional ADR of H1-antihistamine.
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KEYWORD
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Histamine H1 Antagonists, Gynecomastia, Anaphylaxis
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